The burden of influenza B in Europe: a prospective multi-country strain surveillance study using community-based specimens
Seasonal influenza in Humans is caused by influenza type A strains H1N1 and H3N2, strains of influenza B lineage B/Victoria and B/Yamagata.
It is known that in several seasonal influenza Epidemics there is a co- circulation of both sub-types of influenza A and both lineages of influenza B. Much attention has been paid to influenza in the last three decades, especially influenza A (H3N2) and, more recently, pandemic influenza A (H1N1). Many fewer studies have looked specifically at influenza B or comparisons between the influenza B and A.
The objective of the IBGP study is to describe influenza B cases by age and strain lineage, using outpatient data from European countries on clinical symptoms, duration of illness, complications, prescription, and absenteeism.
Study design: Multi-country observational descriptive study
All patients consulting a General Practitioner (GP) or a Paediatrician due to an ILI, during the influenza season 2010-2011 in the enrolled countries.
Cases: Patients presenting ILI who are lab-confirmed influenza B through the sentinel surveillance. Each country will collect all possible cases of influenza B according to the inclusion criteria and follow them up during a period of 28 days after swabbing.
Cohort comparison: Patients presenting ILI lab-negative for influenza B and similarly followed-up as cases.
Data collection: Standardised hard copy case report forms (CRF) developed according to the Protocol objectives.
D0: Time_0 day Standard lab form collected through the GP surveillance system with each specimen collected
D7: Time_7 days (± 2 days) Case-report form will be filled by GP or nurses through a telephone survey or a face to face contact
D28: Time_28 days (± 5 days) Standard questionnaire will be asked by telephone.
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In dit project werken we samen met
Open Rome, Paris, France
Royal College of General Practitioners Research and Surveillance Centre, Birmingham, UK